Aw Sheetz! Ultimate anti-aging remedy is ultrasound therapy? Sound waves show ‘fountain of youth’ effect on cells
I wonder if the same treatment fixes the Medical Counter Measures harm.
Pasted from this URL:
https://studyfinds.org/sound-waves-reversing-aging/
“”Is this too good to be true?’ is the question I often ask. We are examining all aspects of it to see if it really does work.’
GALVESTON, Texas — Ultrasound therapy could delay, stop, or even reverse the aging process, a new study reveals. Scientists in Texas are working on turning back the clock on human cells by zapping them with low frequency waves. The process restarts cell division, awakening them from a “zombie” like state that triggers cell dysfunction and even disease.
Experiments on older mice found that their cells became reinvigorated, helping the animals run further and faster on a treadmill. The treatment even cured one individual’s hunched back, after it worsened initially.
“We treated it twice with ultrasound and it was back to behaving normally. I don’t think rejuvenation is too strong a term,” says lead author Professor Michael Sheetz from the University of Texas, according to a statement provided by South West News Service per New Scientist.
The findings offer hope of warding off frailty, keeping people fit into their 70s and 80s. A clinical trial is in the planning stages to see if the technique is safe and can combat age-related diseases.
“‘Is this too good to be true?’ is the question I often ask. We are examining all aspects of it to see if it really does work,” Prof. Sheetz explains.
The sound waves are much lower than medical scans use
After a certain number of divisions, the cells in our bodies stop dividing and become senescent. Some secrete toxins that cause inflammation. This has been linked to everything from arthritis to Alzheimer’s. Scientists have previously focused on “flushing” out dead and dying cells. This is the first study to show they can actually be “revived.”
Prof. Sheetz and his team found low doses of ultrasound waves made senescent cells from monkeys and humans resume dividing, halting production of chemicals that contaminate healthy counterparts. Human skin cells usually begin wearing out after about 15 divisions. In this case, they reached 24 with no signs of abnormalities.
The ultrasound frequency was less than 100 kilohertz — well below the 2,000 or so used for medical imaging. Tests are continuing to see what the limits are. The study opens the door to growing cells for research, as well as treating people with age-related issues. (2000khz is 2mhz, fyi)
The researchers placed mice in warm water deep enough to cover at least half their bodies. They were between 22 and 25 months-old, equivalent to a human being in their 60s or 70s. Ultrasound waves lose less power travelling through water than they do through air. The lab rodents did better in physical tests compared with peers put in the tub but left untreated. Fluorescent dyes that light up senescent cells were also used to show proportions in the kidneys and pancreas decreased afterwards.
“Aspects of this are still mystifying,” says Prof. Sheetz.
How does the treatment rejuvenate cells?
A possible biological explanation for why this treatment appears to work is ultrasound physically distorts cells, producing similar effects to exercise. In particular, it may be reactivating interior waste disposal systems which grind to a halt in senescent cells.
Prof. Jurgen Gotz from the University of Queensland, who did not take part in the study, described the evidence as convincing.
“But I think more work is needed to define the effective ultrasound parameters,” Prof. Gotz says in a statement from SWNS.
When applying it to people, he pointed out that bones and lungs block ultrasound transmission. His Australian team has found mice given a higher frequency of ultrasound also show improvements in memory. A small trial is already underway to see if this can help people with Alzheimer’s disease.
Ultrasound has been used for decades as a therapy for a wide range of conditions. Prof. Sheetz’s team is planning a trial involving people with osteoarthritis, who will immerse their bodies in water, and people with diabetic foot ulcers, who will be treated using foot baths. Any therapy that boosts cell division could theoretically increase the risk of cancer, but Prof. Sheetz says his team has seen no sign of this after treatment.”
How cool is that eh?
Thats pretty cool.
This below part I think I understand given my bench experiments which showed that the effects on single walled carbon nanotubes and particulate nickel metal with matter immersed in liquid water produced an aggregating effect while effects induced in atmospheric gasses produced radiating effects. The effects observed on the bench were different depending on the material submersed. The nickel powder setup orthagonal to the axis of potential over the volume resulting in what looked like a sandy beach, while the single walled carbon nanotubes aligned on the axis of alignment of the electrodes and self ordered to bridge the gap by moving into position and then Fusing into place with a flash seen underwater. (the nickel would also move into its position then you’d see flashes under water indicating fusion of the tiny particles together.)
“The researchers placed mice in warm water deep enough to cover at least half their bodies. They were between 22 and 25 months-old, equivalent to a human being in their 60s or 70s. Ultrasound waves lose less power travelling through water than they do through air. The lab rodents did better in physical tests compared with peers put in the tub but left untreated. Fluorescent dyes that light up senescent cells were also used to show proportions in the kidneys and pancreas decreased afterwards.
“Aspects of this are still mystifying,” says Prof. Sheetz.”
It would be interesting to know which way the mice were situated for half their bodies to be immersed. If they are on all fours then their stomach would be immersed, which might translate to humans laying on their backs with the water up to just beneath their ear canals. Sort of a front half in air and back half under water. I imagine which parts are in water and which are in air affect how the distortion that results from the impinging sound waves might distribute itself over the form being affected.
We’d also need to know how much power was pumped into the driver and if the shape of the container containing the volume of water needs to be a certain design for it to have better effect. Would be good to see the apparatus as applied to the mice to then see about extrapolating an understanding to attempt human applications.
Upon a quick search for low frequency ultrasound I found this:
“The purpose of this study was to examine whether low frequency (<100 kHz), low intensity (<100 mW/cm2, spatial peak temporal peak) ultrasound can be an effective treatment of venous stasis ulcers, which affect 500 000 patients annually costing over $1 billion per year. Twenty subjects were treated with either 20 or 100 kHz ultrasound for between 15 and 45 min per session for a maximum of four treatments. Healing was monitored by changes in wound area. Additionally, two in vitro studies were conducted using fibroblasts exposed to 20 kHz ultrasound to confirm the ultrasound's effects on proliferation and cellular metabolism. Subjects receiving 20 kHz ultrasound for 15 min showed statistically faster (p < 0.03) rate of wound closure. All five of these subjects fully healed by the fourth treatment session. The in vitro results indicated that 20 kHz ultrasound at 100 mW/cm2 caused an average of 32% increased metabolism (p < 0.05) and 40% increased cell proliferation (p < 0.01) after 24 h when compared to the control, non-treated cells. Although statistically limited, this work supports the notion that low-intensity, low-frequency ultrasound is beneficial for treating venous ulcers.”
Quoted from:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745491/
And this:
“Abstract
This paper details the systematic approach used to develop a viable clinical prototype of a therapeutic ultrasound applicator and discusses the rationale and deliberations that led to the design strategy. The applicator was specifically devised to treat chronic wounds and-to the best of the author's knowledge-is the first truly wearable device with a proven record of reducing healing time, directly translating to a reduction of healthcare costs. The prototype operates in the kHz (20-100) range of frequencies and uses noncavitational and nonthermal levels of ultrasound energy. Hence, in the absence of inertial cavitation and temperature elevation, the tissue-ultrasound interaction is considered to be dependent on stable cavitation (if any) and radiation force. The peak acoustic output pressure amplitude is limited to 55 kPa, corresponding to a spatial peak-temporal peak intensity of 100 mW/cm2. This level of intensity is considered to be safe to apply for extended (up to 4 h) periods of time. The patch-like applicator design is suitable to be embedded in wound dressing. With its lightweight (<20 g) and circular (40 mm dia) disk-shape architecture, the applicator is well suited for chronic wound treatment. A small ( n = 8 ) pilot study on the effects of the applicator on diabetic ulcers (DUs) healing time is presented. The average time to wound closure was 4.7 weeks for subjects treated with the active ultrasound applicator, compared to 12 weeks for subjects treated with a sham applicator, suggesting that patients with DUs may benefit from the proposed treatment.”
Quoted from:
https://pubmed.ncbi.nlm.nih.gov/29993739/
It looks like a 20khz or so ultrasound might be the way to go to attempt experiments at home.
wonder if there will be a slough of low set ultrasound machines coming out like this/ or are settings delicate? https://www.medicaldevicedepot.com/Richmar-US-1000-3rd-Edition-Portable-Ultrasound-Un-p/DU1025.htm?dfw_tracker=3918-102085&msclkid=a67c6ee5645519a61bae0d1b141cc4d5
Can you imagine losing your anus and then regrowing one and it not going exactly as planned? did the new anus show up on its knee or something? :P
"Sea spiders can regrow lost anuses and sex organs - leaving scientists stunned
Researchers have speculated that arthropods' ability to regenerate lost limbs may hold the key to treating human amputees - although in the case of sea spiders, their regrowth did not always go completely to plan."
https://news.sky.com/story/sea-spiders-can-regrow-lost-anuses-and-sex-organs-leaving-scientists-stunned-12794124?utm_source=fark&utm_medium=website&utm_content=link&ICID=ref_fark